Vba2p, A Vacuolar Membrane Protein Involved in Basic Amino Acid Transport in Schizosaccharomyces pombe

Naoko SUGIMOTO; Tomoko IWAKI; Soracom CHARDWIRIYAPREECHA; Masamitsu SHIMAZU; Takayuki SEKITO; Kaoru TAKEGAWA; Yoshimi KAKINUMA

doi:10.1271/bbb.100627

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Vba2p, A Vacuolar Membrane Protein Involved in Basic Amino Acid Transport in Schizosaccharomyces pombe

Naoko SUGIMOTO, Tomoko IWAKI, Soracom CHARDWIRIYAPREECHA, Masamitsu SHIMAZU, Takayuki SEKITO, Kaoru TAKEGAWA, Yoshimi KAKINUMA

著者情報

キーワード: Schizosaccharomyces pombe, vacuolar transporter, amino acid, nitrogen starvation

ジャーナルフリー早期公開
電子付録

論文ID: 100627

DOI https://doi.org/10.1271/bbb.100627

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 10 p.2166

詳細

抄録

A recent study filling the gap in the genome sequence in the left arm of chromosome 2 of Schizosaccharomyces pombe revealed a homolog of budding yeast Vba2p, a vacuolar transporter of basic amino acids. GFP-tagged Vba2p in fission yeast was localized to the vacuolar membrane. Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired. A transient increase in lysine uptake under nitrogen starvation was lowered by this mutation. These findings suggest that Vba2p is involved in basic amino acid transport in S. pombe under diverse conditions.

責任著者(Corresponding author)

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