Atg22p, a Vacuolar Membrane Protein Involved in the Amino Acid Compartmentalization of Schizosaccharomyces pombe

Naoko SUGIMOTO; Tomoko IWAKI; Soracom CHARDWIRIYAPREECHA; Masamitsu SHIMAZU; Miyuki KAWANO; Takayuki SEKITO; Kaoru TAKEGAWA; Yoshimi KAKINUMA

doi:10.1271/bbb.100747

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Atg22p, a Vacuolar Membrane Protein Involved in the Amino Acid Compartmentalization of Schizosaccharomyces pombe

Naoko SUGIMOTO, Tomoko IWAKI, Soracom CHARDWIRIYAPREECHA, Masamitsu SHIMAZU, Miyuki KAWANO, Takayuki SEKITO, Kaoru TAKEGAWA, Yoshimi KAKINUMA

著者情報

キーワード: Schizosaccharomyces pombe, vacuolar membrane, amino acid, transport

ジャーナルフリー早期公開

論文ID: 100747

DOI https://doi.org/10.1271/bbb.100747

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 2 p.385

詳細

抄録

The fission yeast Schizosaccharomyces pombe has a homolog of the budding yeast Atg22p, which is involved in spore formation (Mukaiyama H. et al., Microbiology, 155, 3816–3826 (2009)). GFP-tagged Atg22p in the fission yeast was localized to the vacuolar membrane. Upon disruption of atg22, the amino acid levels of the cellular fraction as well as the vacuolar fraction decreased. The uptake of several amino acids, such as lysine, histidine, and arginine, was impaired in atg22Δ cells. S. pombe Atg22p plays an important role in the compartmentalization of amino acids.

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