Pictet-Spengler Reaction Using Ion-Exchange Resin as a Catalyst and Support for ‘Catch and Release’ Purification

Minoru IZUMI; Takeshi KIDO; Miyu MURAKAMI; Shuhei NAKAJIMA; A GANESAN

doi:10.1271/bbb.100770

This article has now been updated. Please use the final version.

Pictet-Spengler Reaction Using Ion-Exchange Resin as a Catalyst and Support for ‘Catch and Release’ Purification

Minoru IZUMI, Takeshi KIDO, Miyu MURAKAMI, Shuhei NAKAJIMA, A GANESAN

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Keywords: Pictet-Spengler reaction, ion-exchange resin, parallel synthesis, alkaloid, catch and release

JOURNAL FREE ACCESS Advance online publication

Article ID: 100770

DOI https://doi.org/10.1271/bbb.100770

The final version of this article is now available: Vol. 75 (2011) , No. 2 p.391

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Abstract

The Pictet-Spengler reaction between tryptamine and aldehydes was catalyzed by Dowex 50W-X4 acidic ion-exchange resin. The products were obtained from the resin in high purity by ‘catch and release’ without the need for separate chromatographic purification.

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