Pictet-Spengler Reaction Using Ion-Exchange Resin as a Catalyst and Support for ‘Catch and Release’ Purification

Minoru IZUMI; Takeshi KIDO; Miyu MURAKAMI; Shuhei NAKAJIMA; A GANESAN

doi:10.1271/bbb.100770

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Notes

Pictet-Spengler Reaction Using Ion-Exchange Resin as a Catalyst and Support for ‘Catch and Release’ Purification

Minoru IZUMI, Takeshi KIDO, Miyu MURAKAMI, Shuhei NAKAJIMA, A GANESAN

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Keywords: Pictet-Spengler reaction, ion-exchange resin, parallel synthesis, alkaloid, catch and release

JOURNAL FREE ACCESS

2011 Volume 75 Issue 2 Pages 391-392

DOI https://doi.org/10.1271/bbb.100770

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Abstract

The Pictet-Spengler reaction between tryptamine and aldehydes was catalyzed by Dowex 50W-X4 acidic ion-exchange resin. The products were obtained from the resin in high purity by ‘catch and release’ without the need for separate chromatographic purification.

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