Production of Anti-Amyloid β Antibodies in Mice Fed Rice Expressing Amyloid β

Jun NOJIMA; Rika ISHII-KATSUNO; Eugene FUTAI; Noboru SASAGAWA; Yuichiro WATANABE; Taiji YOSHIDA; Shoichi ISHIURA

doi:10.1271/bbb.100861

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Production of Anti-Amyloid β Antibodies in Mice Fed Rice Expressing Amyloid β

Jun NOJIMA, Rika ISHII-KATSUNO, Eugene FUTAI, Noboru SASAGAWA, Yuichiro WATANABE, Taiji YOSHIDA, Shoichi ISHIURA

著者情報

キーワード: Alzheimer’s disease, amyloid beta, an edible vaccine, immune tolerance

ジャーナルフリー早期公開

論文ID: 100861

DOI https://doi.org/10.1271/bbb.100861

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 2 p.396

詳細

抄録

The main signs of Alzheimer’s disease (AD) are cognitive impairment and senile plaques composed of amyloid beta (Aβ) observed in patients’ brains. Therefore, therapy for AD focuses on the removal of Aβ. We developed an “edible vaccine” that employs intestinal immunity with little to no side effects. Rice was utilized as an edible vaccine. It expressed GFP-Aβ42. Aβ rice was administered orally to wild-type (WT) mice causing production of anti-Aβ antibodies. Since Aβ rice was mixed with the cholera toxin B subunit (CTB), antibody against the rice seed protein was also produced. Then, mice were caused to develop immune tolerance against the rice seed protein by oral administration of Aβ rice mixed with CTB. The results indicated that only anti-Aβ antibodies were produced.

責任著者(Corresponding author)

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