Effects of Daintain/AIF-1 on β Cell Dysfunction in INS-1 Cells

Xinyuan HUANG; Yanying ZHAO; Shaohui JIA; Dongjing YAN; Zhengwang CHEN

doi:10.1271/bbb.110317

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Effects of Daintain/AIF-1 on β Cell Dysfunction in INS-1 Cells

Xinyuan HUANG, Yanying ZHAO, Shaohui JIA, Dongjing YAN, Zhengwang CHEN

著者情報

キーワード: daintain/AIF-1, INS-1 cell, β cell dysfunction, type-1 diabetes, cytotoxicity

ジャーナルフリー早期公開

論文ID: 110317

DOI https://doi.org/10.1271/bbb.110317

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 9 p.1842

詳細

抄録

We investigated the effects of daintain/AIF-1, a novel inflammatory cytokine, on INS-1β cells. Cells incubated with daintain/AIF-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and NO production. These deleterious effects of daintain/AIF-1 indicate that daintain/AIF-1 plays important roles in the dysfunction of pancreatic β cells in type-1 diabetes.

責任著者(Corresponding author)

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