10T024A, a New Phenazine Derivative, as a Radical Scavenger and a Prostaglandin, Leukotriene Release Suppressor

Toshikazu KOMODA; Yuta TAMIYA; Masazumi NISHIKAWA

doi:10.1271/bbb.110384

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10T024A, a New Phenazine Derivative, as a Radical Scavenger and a Prostaglandin, Leukotriene Release Suppressor

Toshikazu KOMODA, Yuta TAMIYA, Masazumi NISHIKAWA

著者情報

キーワード: phenazine, 2,2-diphenyl-1-picrylhydrazyl (DPPH), Streptomyces sp., prostaglandin D₂, leukotriene B₄

ジャーナルフリー早期公開

論文ID: 110384

DOI https://doi.org/10.1271/bbb.110384

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 10 p.2056

詳細

抄録

We identified a new radical scavenger, 10T024A (C₁₅H₁₂N₂O₄), from a culture of the Streptomyces sp. Spectroscopic elucidation indicated that this compound is a new phenazine derivative. 10T024A showed radical-scavenging activity with an ED₅₀ of 125 μM. Moreover, it showed prostaglandin D₂ (PGD₂) and leukotriene B₄ (LTB₄) release suppressive activity in rat basophilic leukemia (RBL-2H3) cells, at IC₅₀: 8 μM and 10 μM respectively.

責任著者(Corresponding author)

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