Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR

Ruiqing YAO; Akihito YASUOKA; Asuka KAMEI; Yoshinori KITAGAWA; Tomohiro ROGI; Norifumi TAIEISHI; Nobuo TSURUOKA; Yoshionobu KISO; Takumi MISAKA; Keiko ABE

doi:10.1271/bbb.110444

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引用する場合も本公開記事を引用してください。

Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR

Ruiqing YAO, Akihito YASUOKA, Asuka KAMEI, Yoshinori KITAGAWA, Tomohiro ROGI, Norifumi TAIEISHI, Nobuo TSURUOKA, Yoshionobu KISO, Takumi MISAKA, Keiko ABE

著者情報

キーワード: polyphenol, resveratrol, ellagic acid, constitutive androstane receptor, alcoholic beverage

ジャーナルフリー早期公開

論文ID: 110444

DOI https://doi.org/10.1271/bbb.110444

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 8 p.1635

詳細

抄録

The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol, ellagic acid, β-caryophyllene, myrcene, and xanthohumol. A luciferase assay revealed that ellagic acid and trans-resveratrol activated both human and mouse CAR. Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.

責任著者(Corresponding author)

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