Enhancement of Endothelial Progenitor Cell Numbers and Migration by H1152, a Rho Kinase Specific Inhibitor

Eunju O; Seung Woo LEE; Hyun-Sun LEE; Hee-Suk LIM; Hyun-Young AHN; Jong-Chul SHIN; Yonggoo KIM; Young Ae JOE

doi:10.1271/bbb.110468

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Enhancement of Endothelial Progenitor Cell Numbers and Migration by H1152, a Rho Kinase Specific Inhibitor

Eunju O, Seung Woo LEE, Hyun-Sun LEE, Hee-Suk LIM, Hyun-Young AHN, Jong-Chul SHIN, Yonggoo KIM, Young Ae JOE

著者情報

キーワード: Rho kinase inhibitor, endothelial progenitor cell, H1152, expansion, migration

ジャーナルフリー早期公開

論文ID: 110468

DOI https://doi.org/10.1271/bbb.110468

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 1 p.172

詳細

抄録

Endothelial progenitor cells (EPCs) are applied in the treatment of ischemic diseases. In ex vivo culture of human cord-blood derived EPCs, H1152, (S)-(+)-2-methyl-1-[(4-methyl-5-iso-quinolinyl) sulfonyl]-homopiperazine, markedly increased the number of EPCs. It also induced EPC migration, stimulated the phosphorylation of AKT, and reduced the expression of p27 in the EPCs. Thus H1152 can be used effectively in ex vivo expansion of EPCs.

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