Regulation of Lipid Metabolism by Palmitoleate and Eicosapentaenoic Acid (EPA) in Mice Fed a High-Fat Diet

Sachiko SHIBA; Nobuyo TSUNODA; Masaki WAKUTSU; Etsuko MURAKI; Mariko SONODA; Phyllis S. Y. TAM; Yoko FUJIWARA; Shinji IKEMOTO; Keizo KASONO

doi:10.1271/bbb.110509

This article has now been updated. Please use the final version.

Regulation of Lipid Metabolism by Palmitoleate and Eicosapentaenoic Acid (EPA) in Mice Fed a High-Fat Diet

Sachiko SHIBA, Nobuyo TSUNODA, Masaki WAKUTSU, Etsuko MURAKI, Mariko SONODA, Phyllis S. Y. TAM, Yoko FUJIWARA, Shinji IKEMOTO, Keizo KASONO

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Keywords: palmitoleate, EPA, fish oil, lipid metabolism, high-fat diet

JOURNAL FREE ACCESS Advance online publication

Article ID: 110509

DOI https://doi.org/10.1271/bbb.110509

The final version of this article is now available: Vol. 75 (2011) , No. 12 p.2401

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Abstract

We investigated whether oral administration of palmitoleate ameliorates disorders of lipid metabolism to clarify the effects of one of the components of fish oil. Lipid levels in the liver and plasma were significantly decreased by palmitoleate and by EPA administration. These results suggest that palmitoleate, in addition to EPA, plays a role in the regulation of lipid metabolism by fish oil.

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