Lupeol Supplementation Improves Blood Pressure and Lipid Metabolism Parameters in Stroke-Prone Spontaneously Hypertensive Rats

ARDIANSYAH; Eri YAMAGUCHI; Hitoshi SHIRAKAWA; Keishi HATA; Kazuyuki HIWATASHI; Kousaku OHINATA; Tomoko GOTO; Michio KOMAI

doi:10.1271/bbb.110559

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Lupeol Supplementation Improves Blood Pressure and Lipid Metabolism Parameters in Stroke-Prone Spontaneously Hypertensive Rats

ARDIANSYAH, Eri YAMAGUCHI, Hitoshi SHIRAKAWA, Keishi HATA, Kazuyuki HIWATASHI, Kousaku OHINATA, Tomoko GOTO, Michio KOMAI

著者情報

キーワード: lupeol, blood pressure, lipid metabolism, stroke-prone spontaneously hypertensive rat

ジャーナルフリー早期公開

論文ID: 110559

DOI https://doi.org/10.1271/bbb.110559

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 1 p.183

詳細

抄録

Supplementation with lupeol (0.67 g·kg⁻¹) of the AIN-93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2′-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved in triglyceride and cholesterol synthesis.

責任著者(Corresponding author)

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