Enzymatic Synthesis of 4-Pentulosonate (4-Keto-D-pentonate) from D-Aldopentose and D-Pentonate by Two Different Pathways Using Membrane Enzymes of Acetic Acid Bacteria

Osao ADACHI; Roque A. HOURS; Emiko SHINAGAWA; Yoshihiko AKAKABE; Toshiharu YAKUSHI; Kazunobu MATSUSHITA

doi:10.1271/bbb.110575

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Enzymatic Synthesis of 4-Pentulosonate (4-Keto-D-pentonate) from D-Aldopentose and D-Pentonate by Two Different Pathways Using Membrane Enzymes of Acetic Acid Bacteria

Osao ADACHI, Roque A. HOURS, Emiko SHINAGAWA, Yoshihiko AKAKABE, Toshiharu YAKUSHI, Kazunobu MATSUSHITA

著者情報

キーワード: D-pentonate 4-dehydrogenase, D-aldopentose 4-dehydrogenase, 4-keto-D-aldopentose, 4-keto-D-aldopentose 1-dehydrogenase, 4-pentulosonate

ジャーナルフリー早期公開

論文ID: 110575

DOI https://doi.org/10.1271/bbb.110575

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 12 p.2418

詳細

抄録

4-Keto-D-arabonate (D-threo-pent-4-ulosonate) and 4-keto-D-ribonate (D-erythro-pent-4-ulosonate) were prepared from D-arabinose and D-ribose by two successive reactions of membrane-bound enzymes, D-aldopentose 4-dehydrogenase and 4-keto-D-aldopentose 1-dehydrogenase of Gluconobacter suboxydans IFO 12528. Alternatively, they were prepared from D-arabonate and D-ribonate with another membrane-bound enzyme, D-pentonate 4-dehydrogenase. Analytical data confirmed the chemical structures of the 4-pentulosonates prepared. This is the first report of successful enzymatic synthesis of 4-pentulosonates.

責任著者(Corresponding author)

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