Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Kinetic Analysis for the Degradation of Glycyl-L-leucine and L-Leucyl-glycine in Subcritical Water
Takashi KOBAYASHIRyo FUJITAIncharoensakdi CHAIYAPATHajime MORIAsao HOSODAHisaji TANIGUCHIShuji ADACHI
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JOURNAL FREE ACCESS Advance online publication

Article ID: 110590

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Abstract

Two dipeptides, glycyl-L-leucine (G-L) and L-leucyl-glycine (L-G), the concentrations of which were 10 mmol/L, were degraded in subcritical water in order to understand fully the phenomena occurring during treatment. Treatment was administered in a stainless steel tubular reactor, which was connected to an HPLC pump and immersed in an oil bath at 200–240 °C, with residence times of 10–180 s. When G-L and L-G were treated, L-G and G-L significantly formed, respectively, and then they gradually decreased at every temperature. Irrespective of the kind of substrate, ring formation occurred, and cyclo-(glycyl-L-leucine) was one of the final products. The reaction rate constants related to degradation were estimated under the assumption that all the reactions obeyed first-order kinetics, and the simulated results corresponded well with the experimental ones in every case.

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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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