Effect of the Uncharged Imidazolium Moiety in Adenine on Endothelium-Independent Relaxation in the Contracted Thoracic Aorta of Sprague-Dawley Rats

Shinji TOKUDA; Toshihiko FUKUDA; Yutaro KOBAYASHI; Mitsuru TANAKA; Toshiro MATSUI

doi:10.1271/bbb.110806

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Effect of the Uncharged Imidazolium Moiety in Adenine on Endothelium-Independent Relaxation in the Contracted Thoracic Aorta of Sprague-Dawley Rats

Shinji TOKUDA, Toshihiko FUKUDA, Yutaro KOBAYASHI, Mitsuru TANAKA, Toshiro MATSUI

著者情報

キーワード: adenine, relaxation, imidazolium ring, adenine analogues

ジャーナルフリー早期公開

論文ID: 110806

DOI https://doi.org/10.1271/bbb.110806

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 4 p.828

詳細

抄録

Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC₅₀ value of 0.40±0.12 mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）