Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared from Caulerpa lentillifera

Reiko MAEDA; Tomoaki IDA; Hideshi IHARA; Tatsuji SAKAMOTO

doi:10.1271/bbb.120016

This article has now been updated. Please use the final version.

Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared from Caulerpa lentillifera

Reiko MAEDA, Tomoaki IDA, Hideshi IHARA, Tatsuji SAKAMOTO

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Keywords: Caulerpa lentillifera, β-1,3-xylooligosaccharide, apoptosis, MCF-7 human breast cancer cell

JOURNAL FREE ACCESS Advance online publication

Article ID: 120016

DOI https://doi.org/10.1271/bbb.120016

The final version of this article is now available: Vol. 76 (2012) , No. 5 p.1032

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Abstract

β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.

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