Influence of GABA on Brain Protein Synthesis Mediated by the Mammalian Target on the Rapamycin Pathway

Panicha THANAPREEDAWAT; Miho OHSUMI; Kazutoshi HAYASE; Fumiaki YOSHIZAWA; Hidehiko YOKOGOSHI

doi:10.1271/bbb.120808

This article has now been updated. Please use the final version.

Influence of GABA on Brain Protein Synthesis Mediated by the Mammalian Target on the Rapamycin Pathway

Panicha THANAPREEDAWAT, Miho OHSUMI, Kazutoshi HAYASE, Fumiaki YOSHIZAWA, Hidehiko YOKOGOSHI

Author information

Keywords: γ-aminobutyric acid (GABA), mammalian target of rapamycin (mTOR), S6K1, growth hormone, protein synthesis

JOURNAL FREE ACCESS Advance online publication

Article ID: 120808

DOI https://doi.org/10.1271/bbb.120808

The final version of this article is now available: Vol. 77 (2013) , No. 3 p.660

Details

Abstract

This study determined the influence of γ-aminobutyric acid (GABA) on brain protein synthesis via the mammalian target of rapamycin (mTOR) pathway. Experiments were carried out on three groups of 6-wk-old male rats with 0%, 0.5%, and 1% GABA. The percentage-phosphorylated S6K1 and growth hormone (GH) concentration was significantly increased by the GABA administration. The insulin level was not significantly changed, while the insulin-like growth factor 1 (IGF-1) level was significantly decreased by the GABA administration.

Corresponding author

Register with J-STAGE for free!