Dietary Glucosylceramide Enhances Tight Junction Function in Skin Epidermis via Induction of Claudin-1

Chinatsu KAWADA; Tatsuya HASEGAWA; Mutsuto WATANABE; Yoshihiro NOMURA

doi:10.1271/bbb.120874

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Dietary Glucosylceramide Enhances Tight Junction Function in Skin Epidermis via Induction of Claudin-1

Chinatsu KAWADA, Tatsuya HASEGAWA, Mutsuto WATANABE, Yoshihiro NOMURA

著者情報

キーワード: glucosylceramide, sphingosine, phytosphingosine, tight junction, claudin-1

ジャーナルフリー早期公開

論文ID: 120874

DOI https://doi.org/10.1271/bbb.120874

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 4 p.867

詳細

抄録

Dietary glucosylceramide increased the expression of claudin-1 in UVB-irradiated mouse epidermis. Sphingosine and phytosphingosine, metabolites of glucosylceramide, increased trans-epithelial electrical resistance, and phytosphingosine increased claudin-1 mRNA expression in cultured keratinocytes. Our results indicate that the skin barrier improvement induced by dietary glucosylceramide might be due to enhancement of tight junction function, mediated by increased expression of claudin-1 induced by sphingoid metabolites.

責任著者(Corresponding author)

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