Styrene Altered Clock Gene Expression in Serum-Shocked Cultured Human Fibroblasts

Nicola MANZELLA; Massimo BRACCI; Sara STAFFOLANI; Elisabetta STRAFELLA; Venerando RAPISARDA; Matteo VALENTINO; Monica AMATI; Alfredo COPERTARO; Lory SANTARELLI

doi:10.1271/bbb.120944

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Styrene Altered Clock Gene Expression in Serum-Shocked Cultured Human Fibroblasts

Nicola MANZELLA, Massimo BRACCI, Sara STAFFOLANI, Elisabetta STRAFELLA, Venerando RAPISARDA, Matteo VALENTINO, Monica AMATI, Alfredo COPERTARO, Lory SANTARELLI

著者情報

キーワード: circadian rhythm, biological clock, xenobiotics, styrene, fibroblast

ジャーナルフリー早期公開

論文ID: 120944

DOI https://doi.org/10.1271/bbb.120944

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 6 p.1296

詳細

抄録

The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.

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