Styrene Altered Clock Gene Expression in Serum-Shocked Cultured Human Fibroblasts

Nicola MANZELLA; Massimo BRACCI; Sara STAFFOLANI; Elisabetta STRAFELLA; Venerando RAPISARDA; Matteo VALENTINO; Monica AMATI; Alfredo COPERTARO; Lory SANTARELLI

doi:10.1271/bbb.120944

Environmental Science Note

Styrene Altered Clock Gene Expression in Serum-Shocked Cultured Human Fibroblasts

Nicola MANZELLA, Massimo BRACCI, Sara STAFFOLANI, Elisabetta STRAFELLA, Venerando RAPISARDA, Matteo VALENTINO, Monica AMATI, Alfredo COPERTARO, Lory SANTARELLI

著者情報

キーワード: circadian rhythm, biological clock, xenobiotics, styrene, fibroblast

ジャーナルフリー

2013 年 77 巻 6 号 p. 1296-1298

DOI https://doi.org/10.1271/bbb.120944

View "Advance Publication" version (June 7, 2013).

詳細

抄録

The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.

責任著者(Corresponding author)

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