Assessment of Key Amino-Acid Residues of CD36 in Specific Binding Interaction with an Oxidized Low-Density Lipoprotein

Marie TAKAI; Satoshi TSUZUKI; Yukari MATSUNO; Yuki KOZAI; Ai EGUCHI; Shigenobu MATSUMURA; Kazuo INOUE; Tohru FUSHIKI

doi:10.1271/bbb.130072

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Assessment of Key Amino-Acid Residues of CD36 in Specific Binding Interaction with an Oxidized Low-Density Lipoprotein

Marie TAKAI, Satoshi TSUZUKI, Yukari MATSUNO, Yuki KOZAI, Ai EGUCHI, Shigenobu MATSUMURA, Kazuo INOUE, Tohru FUSHIKI

著者情報

キーワード: CD36, hydrophobic residues, oxidized low-density lipoprotein/oxidized glycerophospholipids, specific binding, synthetic peptides

ジャーナルフリー早期公開

論文ID: 130072

DOI https://doi.org/10.1271/bbb.130072

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 5 p.1134

詳細

抄録

CD36 binds oxidized low-density lipoprotein (oxLDL). A synthetic peptide comprising amino-acid residues 149–168 of mouse CD36 was recently found to bind fluorescence-labeled oxLDL particles. Based on our oxLDL-binding analysis of various synthetic CD36 peptides, we suggest that not only hydrophilic residues (e.g., Lys164 and Lys166) but also hydrophobic ones (e.g., Phe153, Leu158, and Leu161) are critical to binding.

責任著者(Corresponding author)

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