Compensatory Growth of C2C12 Myotubes Induced by the Combined Effect of Lysine Sufficiency and Modulation of IGF-I and Glucocorticoid Levels

Aiko ISHIDA; Kazuki NAKASHIMA; Takahito KYOYA; Masaya KATSUMATA

doi:10.1271/bbb.130412

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Compensatory Growth of C2C12 Myotubes Induced by the Combined Effect of Lysine Sufficiency and Modulation of IGF-I and Glucocorticoid Levels

Aiko ISHIDA, Kazuki NAKASHIMA, Takahito KYOYA, Masaya KATSUMATA

著者情報

キーワード: compensatory growth, lysine, C2C12 myotubes, insulin-like growth factor-I (IGF-I), glucocorticoid

ジャーナルフリー早期公開

論文ID: 130412

DOI https://doi.org/10.1271/bbb.130412

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 11 pp. 2302-2304

詳細

抄録

We have reported that a change from a lysine-deficient diet to a lysine-sufficient diet induced compensatory growth in rats and pigs. The aim of the present study was to determine whether compensatory growth of C2C12 myotubes occurs only by sufficiency of lysine or also by the synergic effect of sufficiency of lysine and modulation of the levels of insulin-like growth factor-I (IGF-I) and glucocorticoid in a medium. The results provide the first evidence of compensatory growth of C2C12 myotubes induced by sufficiency of a single amino acid in combination with modulation of the levels of IGF-I and glucocorticoid.

責任著者(Corresponding author)

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