Lysophosphatidylcholine Potentiates BDNF-Induced TrkB Phosphorylation and Downstream Signals in Cerebellar Granule Neurons

WUHANQIMUGE; Manabu ARIOKA

doi:10.1271/bbb.130622

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Lysophosphatidylcholine Potentiates BDNF-Induced TrkB Phosphorylation and Downstream Signals in Cerebellar Granule Neurons

WUHANQIMUGE, Manabu ARIOKA

著者情報

キーワード: Akt, brain-derived growth factor, lysophosphatidylcholine, mitogen-activated protein kinase, cerebellar granule neurons

ジャーナルフリー早期公開

論文ID: 130622

DOI https://doi.org/10.1271/bbb.130622

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 12 pp. 2510-2513

詳細

抄録

We found that brain-derived neurotrophic factor (BDNF)-induced phosphorylation of mitogen-activated protein kinase (MAPK) and Akt in cerebellar granule neurons was specifically potentiated by LPC. LPC also augmented the BDNF-induced phosphorylation of TrkB, the receptor for BDNF. In TrkB-transfected CHO-K1 cells, LPC potentiated BDNF-induced MAPK phosphorylation. These results suggest that LPC plays a role in BDNF-TrkB signaling by regulating the activation of TrkB.

責任著者(Corresponding author)

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