MurA as a Primary Target of Tulipalin B and 6-Tuliposide B

Kengo SHIGETOMI; Sanne Harder OLESEN; Yan YANG; Shinya MITSUHASHI; Ernst SCHÖNBRUNN; Makoto UBUKATA

doi:10.1271/bbb.130663

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MurA as a Primary Target of Tulipalin B and 6-Tuliposide B

Kengo SHIGETOMI, Sanne Harder OLESEN, Yan YANG, Shinya MITSUHASHI, Ernst SCHÖNBRUNN, Makoto UBUKATA

著者情報

キーワード: tuliposide, tulipalin, MurA

ジャーナルフリー早期公開
電子付録

論文ID: 130663

DOI https://doi.org/10.1271/bbb.130663

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 12 pp. 2517-2519

詳細

抄録

(−)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.

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