Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Notes
MurA as a Primary Target of Tulipalin B and 6-Tuliposide B
Kengo SHIGETOMISanne Harder OLESENYan YANGShinya MITSUHASHIErnst SCHÖNBRUNNMakoto UBUKATA
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キーワード: tuliposide, tulipalin, MurA
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2013 年 77 巻 12 号 p. 2517-2519

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(−)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.

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© 2013 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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