Egg Yolk Soluble Protein Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells

MinYoung JI; Kang-Hyun LEEM; Mujo KIM; Hye Kyung KIM

doi:10.1271/bbb.60217

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Egg Yolk Soluble Protein Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells

MinYoung JI, Kang-Hyun LEEM, Mujo KIM, Hye Kyung KIM

著者情報

キーワード: yolk soluble protein, MC3T3-E1 pre-osteoblastic cell, proliferation, alkaline phosphatase activity, collagen

ジャーナルフリー早期公開

論文ID: 60217

DOI https://doi.org/10.1271/bbb.60217

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 5 p.1327

詳細

抄録

We determined the effects of yolk water-soluble protein (YSP) on bone formation in pre-osteoblastic MC3T3-E1 cells. YSP (50–5,000 μg/ml) increased cell proliferation and collagen content. Alkaline phosphatase (ALP) activity was also increased by YSP treatment. After enhancement of ALP activity, significant augmentation of calcification was observed. These results suggest that YSP is a promising agent for the prevention and treatment of bone loss.

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