An Anti-Estrogenic Lignan Glycoside, Tracheloside, from Seeds of Carthamus tinctorius

Hye Hyun YOO; Jeong Hill PARK; Sung Won KWON

doi:10.1271/bbb.60290

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An Anti-Estrogenic Lignan Glycoside, Tracheloside, from Seeds of Carthamus tinctorius

Hye Hyun YOO, Jeong Hill PARK, Sung Won KWON

著者情報

キーワード: Carthamus tinctorius, tracheloside, anti-estrogenic activity, Ishikawa cell, bioassay-linked HPLC-ELSD

ジャーナルフリー早期公開

論文ID: 60290

DOI https://doi.org/10.1271/bbb.60290

この記事には本公開記事があります。

The final version of this article is now available: Vol. 70 (2006) , No. 11 p.2783

詳細

抄録

The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC₅₀ value of 0.31 μg/ml, a level of inhibition comparable to that of tamoxifen (IC₅₀ = 0.43 μg/ml).

責任著者(Corresponding author)

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