Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans

Satoshi YAMAUCHI; Takuya SUGAHARA; Yuki NAKASHIMA; Koki ABE; Yoshimasa HAYASHI; Koichi AKIYAMA; Taro KISHIDA; Masafumi MARUYAMA

doi:10.1271/bbb.60353

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引用する場合も本公開記事を引用してください。

Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans

Satoshi YAMAUCHI, Takuya SUGAHARA, Yuki NAKASHIMA, Koki ABE, Yoshimasa HAYASHI, Koichi AKIYAMA, Taro KISHIDA, Masafumi MARUYAMA

著者情報

キーワード: matairesinol, cytotoxic activity, oxidized matairesinol

ジャーナルフリー早期公開

論文ID: 60353

DOI https://doi.org/10.1271/bbb.60353

この記事には本公開記事があります。

The final version of this article is now available: Vol. 70 (2006) , No. 12 p.2942

詳細

抄録

The cytotoxic activity for colon 26 cell line of matairesinol, oxidized matairesinol, 9,9′-epoxylignan and oxidized 9,9′-epoxylignan were examined. (−)-Matairesinol (Mat 1) showed greatest cytotoxic activity (LC₅₀=9 μg/ml) of the lactone-type lignans. 7,7′-Oxomatairesinol having same steric configuration as that of (−)-matairesinol showed greater activity (LC₅₀=25 μg/ml) than hydroxy or mono-oxomatairesinol. The activities of 9,9′-epoxylignan and 7,7′-oxo-9,9′-epoxylignan having same steric configurations as (−)-matairesinol were weaker than that of corresponding matairesinols. Different activity levels were observed between enantiomers.

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