Identification of a Soluble NADPH Oxidoreductase (BmNOX) with Antiviral Activites in the Gut Juice of Bombyx mori

Ruchita SELOT; Virendra KUMAR; Sunita SHUKLA; Kumar CHANDRAKUNTAL; Mopidevi BRAHMARAJU; SB DANDIN; Malini LALORAYA; Pradeep G. KUMAR

doi:10.1271/bbb.60450

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Identification of a Soluble NADPH Oxidoreductase (BmNOX) with Antiviral Activites in the Gut Juice of Bombyx mori

Ruchita SELOT, Virendra KUMAR, Sunita SHUKLA, Kumar CHANDRAKUNTAL, Mopidevi BRAHMARAJU, SB DANDIN, Malini LALORAYA, Pradeep G. KUMAR

著者情報

キーワード: silkworm, anti-viral, NOX, virus resistance

ジャーナルフリー早期公開

論文ID: 60450

DOI https://doi.org/10.1271/bbb.60450

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 1 p.200

詳細

抄録

Silkworms show high variability in silk quality and disease resistance. Attempts are on to combine the disease tolerance of multivoltine races and the silk quality of bivoltine races to generate new races with desirable phenotypic traits. We report the identification of a 26.5-kDa protein that is overexpressed in the gut juice of disease-resistant multivoltine races and that has anti-BmNVP activity. We have characterized this protein as a soluble NADH-oxidoreductase-like protein (BmNOX). Treatment of live BmNPV particles with BmNOX inhibited the capability of the viral particles to infect BmN cells in vitro.

責任著者(Corresponding author)

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