Ferulic Acid Supplementation Prevents Trimethyltin-Induced Cognitive Deficits in Mice

Mi Jeong KIM; Soo Jung CHOI; Seung-Taik LIM; Hye Kyung KIM; Ho Jin HEO; Eun-Ki KIM; Woo Jin JUN; Hong Yon CHO; Young Jun KIM; Dong-Hoon SHIN

doi:10.1271/bbb.60564

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Ferulic Acid Supplementation Prevents Trimethyltin-Induced Cognitive Deficits in Mice

Mi Jeong KIM, Soo Jung CHOI, Seung-Taik LIM, Hye Kyung KIM, Ho Jin HEO, Eun-Ki KIM, Woo Jin JUN, Hong Yon CHO, Young Jun KIM, Dong-Hoon SHIN

著者情報

キーワード: choline acetyltransferase, cognitive function, ferulic acid (4-hydroxy-3-methoxycinnamic acid), trimethyltin

ジャーナルフリー早期公開

論文ID: 60564

DOI https://doi.org/10.1271/bbb.60564

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 4 p.1063

詳細

抄録

This study’s objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

責任著者(Corresponding author)

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