Synthesis of Lipid Derivatives of Pyrrole Polyamide and Their Biological Activity

Masahiko YAMAMOTO; Changjin ZHU; Lui YI; Zheng RONG; Yoshie MIURA; Minoru IZUMI; Shuhei NAKAJIMA; Ken-ichi TANAMOTO; Sakayu SHIMIZU; Naomichi BABA

doi:10.1271/bbb.60650

This article has now been updated. Please use the final version.

Synthesis of Lipid Derivatives of Pyrrole Polyamide and Their Biological Activity

Masahiko YAMAMOTO, Changjin ZHU, Lui YI, Zheng RONG, Yoshie MIURA, Minoru IZUMI, Shuhei NAKAJIMA, Ken-ichi TANAMOTO, Sakayu SHIMIZU, Naomichi BABA

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Keywords: pyrrole polyamide, lipid, phospholipid, cancer cell, human immunodeficiency virus (HIV)-II

JOURNAL FREE ACCESS Advance online publication

Article ID: 60650

DOI https://doi.org/10.1271/bbb.60650

The final version of this article is now available: Vol. 71 (2007) , No. 4 p.1078

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Abstract

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

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