Synthesis of Lipid Derivatives of Pyrrole Polyamide and Their Biological Activity

Masahiko YAMAMOTO; Changjin ZHU; Lui YI; Zheng RONG; Yoshie MIURA; Minoru IZUMI; Shuhei NAKAJIMA; Ken-ichi TANAMOTO; Sakayu SHIMIZU; Naomichi BABA

doi:10.1271/bbb.60650

Organic Chemistry Notes

Synthesis of Lipid Derivatives of Pyrrole Polyamide and Their Biological Activity

Masahiko YAMAMOTO, Changjin ZHU, Lui YI, Zheng RONG, Yoshie MIURA, Minoru IZUMI, Shuhei NAKAJIMA, Ken-ichi TANAMOTO, Sakayu SHIMIZU, Naomichi BABA

Author information

Masahiko YAMAMOTO
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University
Changjin ZHU
School of Chemical Engineering & Environment, Beijing Institute of Technology
Lui YI
School of Chemical Engineering & Environment, Beijing Institute of Technology
Zheng RONG
School of Chemical Engineering & Environment, Beijing Institute of Technology
Yoshie MIURA
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University
Minoru IZUMI
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University
Shuhei NAKAJIMA
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University
Ken-ichi TANAMOTO
National Institute of Health Sciences, Division of Food Additives
Sakayu SHIMIZU
Department of Applied Bioscience, Graduate School of Agriculture, Kyoto University
Naomichi BABA
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University

Keywords: pyrrole polyamide, lipid, phospholipid, cancer cell, human immunodeficiency virus (HIV)-II

JOURNAL FREE ACCESS

2007 Volume 71 Issue 4 Pages 1078-1082

DOI https://doi.org/10.1271/bbb.60650

View "Advance Publication" version (April 7, 2007).

Details

Abstract

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

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