Cadmium Cation Increases the Production and mRNA Levels of Insulin-Like Growth Factor-Binding Protein-1 in HepG2

Abstract

The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cd²⁺) at 3 μM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 μM of Cd²⁺. These results suggest that Cd²⁺ impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.