Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase

Nobuhiro ABURAI; Yasuaki ESUMI; Hiroyuki KOSHINO; Naoyuki NISHIZAWA; Ken-ichi KIMURA

doi:10.1271/bbb.70068

This article has now been updated. Please use the final version.

Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase

Nobuhiro ABURAI, Yasuaki ESUMI, Hiroyuki KOSHINO, Naoyuki NISHIZAWA, Ken-ichi KIMURA

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Keywords: histone deacetylase, linoleic acid, proso millet, Japanese millet, anti-tumor activity

JOURNAL FREE ACCESS Advance online publication

Article ID: 70068

DOI https://doi.org/10.1271/bbb.70068

The final version of this article is now available: Vol. 71 (2007) , No. 8 p.2061

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Abstract

Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC₅₀=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC₅₀=68 μM) and prostate cancer LNCaP cells (IC₅₀=193 μM). Millet containing linoleic acid might have anti-tumor activity.

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