Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase

Nobuhiro ABURAI; Yasuaki ESUMI; Hiroyuki KOSHINO; Naoyuki NISHIZAWA; Ken-ichi KIMURA

doi:10.1271/bbb.70068

Food & Nutrition Science Notes

Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase

Nobuhiro ABURAI, Yasuaki ESUMI, Hiroyuki KOSHINO, Naoyuki NISHIZAWA, Ken-ichi KIMURA

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Keywords: histone deacetylase, linoleic acid, proso millet, Japanese millet, anti-tumor activity

JOURNAL FREE ACCESS

2007 Volume 71 Issue 8 Pages 2061-2064

DOI https://doi.org/10.1271/bbb.70068

View "Advance Publication" version (August 7, 2007).

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Abstract

Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC₅₀=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC₅₀=68 μM) and prostate cancer LNCaP cells (IC₅₀=193 μM). Millet containing linoleic acid might have anti-tumor activity.

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