Analyses of Native Disulfide Bond Formations in the Early Stage of the Folding Process in Mutant Lysozymes Where the Long-Range Interactions in the Denatured State Were Modulated

Tomonori MISHIMA; Takatoshi OHKURI; Taiji IMOTO; Tadashi UEDA

doi:10.1271/bbb.70155

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Analyses of Native Disulfide Bond Formations in the Early Stage of the Folding Process in Mutant Lysozymes Where the Long-Range Interactions in the Denatured State Were Modulated

Tomonori MISHIMA, Takatoshi OHKURI, Taiji IMOTO, Tadashi UEDA

著者情報

キーワード: folding, lysozyme, disulfide bond (SS bond) formation, denatured state

ジャーナルフリー早期公開

論文ID: 70155

DOI https://doi.org/10.1271/bbb.70155

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 8 p.2072

詳細

抄録

In order to clarify whether modulation of long-range interactions in the denatured state affect native disulfide bond (SS bond) formations of hen egg white lysozyme (HEL) containing a pair of cysteine residues, we examined the extent of SS bond formation among 12 variants containing a pair of cysteines. The loss of clusters 5 and 6 in the denatured state affected the formation of Cys30-115 and Cys6-127 respectively.

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