Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency

Norihiro MUTOH; Satoko KITAJIMA

doi:10.1271/bbb.70307

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Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency

Norihiro MUTOH, Satoko KITAJIMA

著者情報

キーワード: chronological aging, sir2, glutathione, superoxide dismutase, Schizosaccharomyces pombe

ジャーナルフリー早期公開

論文ID: 70307

DOI https://doi.org/10.1271/bbb.70307

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 11 p.2841

詳細

抄録

A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation.

責任著者(Corresponding author)

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