United Graduate School of Agricultural Sciences, Kagoshima University Department of Biological Sciences, Okinawa Prefectural Institute of Health and Environment
Seiko MATSUDA
Department of Biological Sciences, Okinawa Prefectural Institute of Health and Environment
Koki TERADA
Department of Biological Sciences, Okinawa Prefectural Institute of Health and Environment
Hironori IWASAKI
Division of Molecular Biotechnology and Center of Molecular Bioscience, University of the Ryukyus
Hirosuke OKU
Division of Molecular Biotechnology and Center of Molecular Bioscience, University of the Ryukyus
Published: February 23, 2008Received: August 22, 2007Available on J-STAGE: -Accepted: November 05, 2007
Advance online publication: February 07, 2008
Revised: -
This study describes the first isolation of hemorrhagic metalloproteinase HR1b from the venom of Okinawa habu, and its cDNA cloning. The substrate specificity of isolated HR1b definitely differed from that of HR1a, further supporting the presence of a metalloproteinase distinguishable from HR1a in the venom of Okinawa habu. The deduced amino acid sequence of HR1b showed 99.67% identity with HR1b of Amami habu, with only two amino acid residue replacements.
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