The Occurrence of HR1b in the Venom of the Snake Okinawa Habu (Protobothrops flavoviridis)

Nobuya MORINE; Seiko MATSUDA; Koki TERADA; Hironori IWASAKI; Hirosuke OKU

doi:10.1271/bbb.70540

Biochemistry & Molecular Biology Notes

The Occurrence of HR1b in the Venom of the Snake Okinawa Habu (Protobothrops flavoviridis)

Nobuya MORINE, Seiko MATSUDA, Koki TERADA, Hironori IWASAKI, Hirosuke OKU

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Keywords: hemorrhagic metalloproteinase, HR1b, Protobothrops flavoviridis, Okinawa habu

JOURNAL FREE ACCESS

2008 Volume 72 Issue 2 Pages 591-594

DOI https://doi.org/10.1271/bbb.70540

View "Advance Publication" version (February 7, 2008).

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Abstract

This study describes the first isolation of hemorrhagic metalloproteinase HR1b from the venom of Okinawa habu, and its cDNA cloning. The substrate specificity of isolated HR1b definitely differed from that of HR1a, further supporting the presence of a metalloproteinase distinguishable from HR1a in the venom of Okinawa habu. The deduced amino acid sequence of HR1b showed 99.67% identity with HR1b of Amami habu, with only two amino acid residue replacements.

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