Long-Term Supplementation of Docosahexaenoic Acid–Rich, Eicosapentaenoic Acid-Free Microalgal Oil in n-3 Fatty Acid-Deficient Rat Pups

Abstract

Rat pups deficient in n-3 fatty acids received an oral administration of docosahexaenoic acid (DHA)-rich, eicosapentaenoic acid (EPA)-free microalgal oil (DMO) or fish oil (FO). DMO administration almost restored liver EPA to the level of the control diet-fed dam’s pups, but FO administration did not. This suggests that EPA could be recovered in the liver, even though EPA-free DMO was supplemented.