Low-Molecular-Weight Hyaluronan Permeates through Human Intestinal Caco-2 Cell Monolayers via the Paracellular Pathway

Nozomi HISADA; Hideo SATSU; Akira MORI; Mamoru TOTSUKA; Jun-ichi KAMEI; Takashi NOZAWA; Makoto SHIMIZU

doi:10.1271/bbb.70748

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Low-Molecular-Weight Hyaluronan Permeates through Human Intestinal Caco-2 Cell Monolayers via the Paracellular Pathway

Nozomi HISADA, Hideo SATSU, Akira MORI, Mamoru TOTSUKA, Jun-ichi KAMEI, Takashi NOZAWA, Makoto SHIMIZU

著者情報

キーワード: hyaluronan, Caco-2, tight junction, paracallular pathway

ジャーナルフリー早期公開

論文ID: 70748

DOI https://doi.org/10.1271/bbb.70748

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 4 p.1111

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抄録

The intestinal permeability of low-molecular-weight hyaluronan (LMW-HA) was investigated by using cultured monolayers of Caco-2 cells. The amount of LMW-HA that permeated the Caco-2 monolayers was measured by a carbazole assay. The permeability of LMW-HA increased inversely with the molecular size and was dose-dependent. The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway.

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