Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts

Yusuke KOBAYASHI; Risa SAKEMURA; Atsuko KUMAGAI; Emi SUMIKAWA; Michihiko FUJII; Dai AYUSAWA

doi:10.1271/bbb.70760

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Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts

Yusuke KOBAYASHI, Risa SAKEMURA, Atsuko KUMAGAI, Emi SUMIKAWA, Michihiko FUJII, Dai AYUSAWA

著者情報

キーワード: cellular senescence, nuclear swelling, MAP kinase, excess thymidine

ジャーナルフリー早期公開

論文ID: 70760

DOI https://doi.org/10.1271/bbb.70760

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 4 p.1122

詳細

抄録

Excess thymidine induced premature senescence in normal human fibroblasts (TIG-7), with induction of typical senescence markers. Nuclear swelling, as well as cell swelling, was clearly observed in these senescent cells. Simultaneous addition of MAP kinase inhibitors, U0126, SB203580, and SP60025, effectively suppressed induction of premature senescence and senescence markers.

責任著者(Corresponding author)

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