Chiisanoside Is Not Absorbed but Inhibits Oil Absorption in the Small Intestine of Rodents

Kazuma YOSHIZUMI; Kaeko MUROTA; Shiro WATANABE; Hironori TOMI; Tomoko TSUJI; Junji TERAO

doi:10.1271/bbb.70761

This article has now been updated. Please use the final version.

Chiisanoside Is Not Absorbed but Inhibits Oil Absorption in the Small Intestine of Rodents

Kazuma YOSHIZUMI, Kaeko MUROTA, Shiro WATANABE, Hironori TOMI, Tomoko TSUJI, Junji TERAO

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Keywords: chiisanoside, 3, 4-seco-lupane triterpenoid saponin, Acanthopanax sessiliflorus, lipase inhibitor, intestinal absorption

JOURNAL FREE ACCESS Advance online publication

Article ID: 70761

DOI https://doi.org/10.1271/bbb.70761

The final version of this article is now available: Vol. 72 (2008) , No. 4 p.1126

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Abstract

Chiisanoside is the main component of Acanthopanax sessiliflorus leaves. Simultaneous administration of chiisanoside resulted in a decrease in the plasma TG level and increase of undigested TG in the intestinal lumen after oil gavage to mice. This suggests that chiisanoside has the potential to prevent obesity as a lipase inhibitor which suppresses fat absorption in vivo.

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