Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis (Quaternary Ammonium Salts)

Naokazu KUMURA; Hirotaka FURUKAWA; Michiyo KOBAYASHI; Arnold N. ONYANGO; Minoru IZUMI; Shuhei NAKAJIMA; Hye-Sook KIM; Yusuke WATAYA; Naomichi BABA

doi:10.1271/bbb.80571

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis (Quaternary Ammonium Salts)

Naokazu KUMURA, Hirotaka FURUKAWA, Michiyo KOBAYASHI, Arnold N. ONYANGO, Minoru IZUMI, Shuhei NAKAJIMA, Hye-Sook KIM, Yusuke WATAYA, Naomichi BABA

著者情報

キーワード: tetraoxane, bis (quaternary ammonium salts), malaria, reactive oxygen species

ジャーナルフリー早期公開

論文ID: 80571

DOI https://doi.org/10.1271/bbb.80571

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 1 p.217

詳細

抄録

Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis (quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2-propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a–5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）