Genetic Interaction between Ribosome Biogenesis and Inositol Polyphosphate Metabolism in Saccharomyces cerevisiae

Chihiro HORIGOME; Ryo IKEDA; Takafumi OKADA; Kazuhiko TAKENAMI; Keiko MIZUTA

doi:10.1271/bbb.80599

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Genetic Interaction between Ribosome Biogenesis and Inositol Polyphosphate Metabolism in Saccharomyces cerevisiae

Chihiro HORIGOME, Ryo IKEDA, Takafumi OKADA, Kazuhiko TAKENAMI, Keiko MIZUTA

著者情報

キーワード: ribosome biogenesis, inositol polyphosphate, Saccharomyces cerevisiae, RRS1, KCS1

ジャーナルフリー早期公開

論文ID: 80599

DOI https://doi.org/10.1271/bbb.80599

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 2 p.443

詳細

抄録

Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.

責任著者(Corresponding author)

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