Banana Peel Extract Suppressed Prostate Gland Enlargement in Testosterone-Treated Mice

Kiichiro AKAMINE; Tomoyuki KOYAMA; Kazunaga YAZAWA

doi:10.1271/bbb.80770

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Banana Peel Extract Suppressed Prostate Gland Enlargement in Testosterone-Treated Mice

Kiichiro AKAMINE, Tomoyuki KOYAMA, Kazunaga YAZAWA

著者情報

キーワード: suppressive effect on benign prostate hyperplasia, inhibitor of 5alpha-reductase, banana peel extract, anti-androgen effect, mice

ジャーナルフリー早期公開

論文ID: 80770

DOI https://doi.org/10.1271/bbb.80770

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 9 p.1911

詳細

抄録

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

責任著者(Corresponding author)

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