Isolation of Antibabesial Compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis

Kazuaki YAMADA; SUBEKI; Kensuke NABETA; Masahiro YAMASAKI; Ken KATAKURA; Hideyuki MATSUURA

doi:10.1271/bbb.80784

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Isolation of Antibabesial Compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis

Kazuaki YAMADA, SUBEKI, Kensuke NABETA, Masahiro YAMASAKI, Ken KATAKURA, Hideyuki MATSUURA

著者情報

キーワード: Babesia gibsoni, antibabesial compound, Curcuma xanthorrhiza, Brucea javanica, Excoecaria cochinchinensis

ジャーナルフリー早期公開

論文ID: 80784

DOI https://doi.org/10.1271/bbb.80784

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 3 p.776

詳細

抄録

One new curcuminoid, 3′-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1–4, and diminazene aceturate were studied with IC₅₀ values of 16.6, 7.6, 15.6, 10.0, and 0.6 μg/ml, respectively.

責任著者(Corresponding author)

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