Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Organic Chemistry Notes
Isolation of Antibabesial Compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis
Kazuaki YAMADASUBEKIKensuke NABETAMasahiro YAMASAKIKen KATAKURAHideyuki MATSUURA
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2009 年 73 巻 3 号 p. 776-780

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One new curcuminoid, 3′-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 14, and diminazene aceturate were studied with IC50 values of 16.6, 7.6, 15.6, 10.0, and 0.6 μg/ml, respectively.
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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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