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Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (−)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats
Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University
Miki TSUTSUI
Division of Applied Chemistry in Bioscience, Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
Iwao SAKANE
Central Research Institute, Ito En Ltd.
Hitoshi ASHIDA
Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University Division of Applied Chemistry in Bioscience, Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
Published: May 23, 2009Received: December 09, 2008Available on J-STAGE: -Accepted: January 14, 2009
Advance online publication: May 07, 2009
Revised: -
The suppression of cytochrome P450 1A1 (CYP1A1) expression was examined in mouse hepatoma Hepa-1c1c7 cells treated with serum prepared from (−)-epigallocatechin-3-gallate- and green tea extract-administered rats. Catechins were found in the rat plasma after the administration. In Hepa-1c1c7 cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 expression was suppressed by treatment with the rat serum. It is concluded that catechins can possibly modulate CYP1A1 expression.
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