Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (−)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats

Itsuko FUKUDA; Miki TSUTSUI; Iwao SAKANE; Hitoshi ASHIDA

doi:10.1271/bbb.80868

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (−)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats

Itsuko FUKUDA, Miki TSUTSUI, Iwao SAKANE, Hitoshi ASHIDA

著者情報

キーワード: tea catechin, cytochrome P450 1A1, dioxin, hepatocyte, rat plasma catechin

ジャーナルフリー早期公開

論文ID: 80868

DOI https://doi.org/10.1271/bbb.80868

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 5 p.1206

詳細

抄録

The suppression of cytochrome P450 1A1 (CYP1A1) expression was examined in mouse hepatoma Hepa-1c1c7 cells treated with serum prepared from (−)-epigallocatechin-3-gallate- and green tea extract-administered rats. Catechins were found in the rat plasma after the administration. In Hepa-1c1c7 cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 expression was suppressed by treatment with the rat serum. It is concluded that catechins can possibly modulate CYP1A1 expression.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）