Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells

Yuriko YAMAOKA; Kenji OHGUCHI; Tomohiro ITOH; Yoshinori NOZAWA; Yukihiro AKAO

doi:10.1271/bbb.80880

This article has now been updated. Please use the final version.

Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells

Yuriko YAMAOKA, Kenji OHGUCHI, Tomohiro ITOH, Yoshinori NOZAWA, Yukihiro AKAO

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Keywords: melanin, melanogenesis, tyrosinase, theaflavins, black tea

JOURNAL FREE ACCESS Advance online publication

Article ID: 80880

DOI https://doi.org/10.1271/bbb.80880

The final version of this article is now available: Vol. 73 (2009) , No. 6 p.1429

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Abstract

In this study, we examined the effects of theaflavins, polyphenols in black tea, on α melanocyte-stimulating hormone (αMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3′-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.

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